Post menopausal hormonal replacement therapy
Estero gen alone increases the risk whereas if it is combined with progesterone then there is hardly any risk so it should ideally be taken in combined firm.
Obesity
Fat in the body is the source of excess of esterogen especially in post menopausal females. This excess estero gen increases the risk of endometrial cancer.
High fat diet especially animal fat.
This increase fat in the body which increase the risk of endometrial cancer.
Sedentary habits
Lack of physical activity increases the obesity which promotes endometrial cancer.
Nulliparity or infertility
Pregnancy decreases the continued exposure to high level of esterogen which in turn reduces the risk of endometrial cancer so lack of pregnancy increases the risk of endometrial cancer
Age
Old the age more is the risk
Early menarche and late menopause leads to excess exposure to esterogen in the life of female thereby increasing the risk.
Tamoxifen therapy for breast cancer
It acts like estrogen for endometrium so it increases the risk especially in post menopausal females so regular monitoring is essential when on tamoxifen therapy.
Estrogen secreting tumours
Like granulosa cell tumours
Other risk factors
Smoking
Genetic like LYNCH SYNDROME
Exposure to pelvic radiation
PCOS Polycystic ovarian syndrome
